GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs801193 | 1 | rs10234018 | chr7:66146284 | CRCP | chr7:65579805-65619551:+ | 0.15 | 3.96 | 8.05E-5 | Aortic root size |
| BRCA | cis | rs801193 | 1 | rs10234018 | chr7:66146284 | LOC493754 | chr7:65993446-66057363:- | 0.15 | 3.94 | 8.62E-5 | Aortic root size |
| BRCA | cis | rs14978 | 1 | rs10235395 | chr7:12286050 | VWDE | chr7:12370509-12443852:- | -0.15 | -4.04 | 5.8E-5 | Response to amphetamines |
| BRCA | cis | rs12101261 | 1 | rs1023586 | chr14:81462283 | TSHR | chr14:81421869-81612646:+ | -0.13 | -3.86 | 0.00012 | Graves' disease |
| BRCA | cis | rs14978 | 1 | rs10236369 | chr7:12280838 | VWDE | chr7:12370509-12443852:- | -0.13 | -3.67 | 0.000259 | Response to amphetamines |
| BRCA | cis | rs2157926 | 1 | rs10239908 | chr7:87497323 | DBF4 | chr7:87505544-87538856:+ | 0.13 | 3.47 | 0.000532 | Bone mineral density (spine) and age at menarche |
| BRCA | cis | rs13240464 | 1 | rs10242018 | chr7:110929652 | IMMP2L | chr7:110303110-111202538:- | 0.15 | 4.17 | 3.29E-5 | Schizophrenia |
| BRCA | cis | rs7794364 | 1 | rs10242542 | chr7:117522914 | CTTNBP2 | chr7:117350708-117513561:- | -0.13 | -3.93 | 9.0E-5 | Idiopathic osteonecrosis of the femoral head |
| BRCA | cis | rs9986765 | 1 | rs10243198 | chr7:142822210 | TMEM139 | chr7:142982044-142985140:+ | -0.2 | -3.43 | 0.000631 | Dermatomyositis |
| BRCA | cis | rs7794364 | 1 | rs10245031 | chr7:117498461 | CTTNBP2 | chr7:117350708-117513561:- | -0.14 | -4.09 | 4.62E-5 | Idiopathic osteonecrosis of the femoral head |
| BRCA | cis | rs1451375 | 1 | rs10247443 | chr7:50620586 | FIGNL1 | chr7:50511834-50518088:- | -0.13 | -4.58 | 5.28E-6 | Malaria |
| BRCA | cis | rs2243480 | 1 | rs10247526 | chr7:65780696 | CCT6P1 | chr7:65216092-65228661:+ | -0.31 | -6.49 | 1.3E-10 | Diabetic kidney disease |
| BRCA | cis | rs2243480 | 1 | rs10247526 | chr7:65780696 | CRCP | chr7:65579805-65619551:+ | 0.22 | 3.69 | 0.000238 | Diabetic kidney disease |
| BRCA | cis | rs2243480 | 1 | rs10247526 | chr7:65780696 | LOC493754 | chr7:65993446-66057363:- | -0.22 | -3.68 | 0.00025 | Diabetic kidney disease |
| BRCA | cis | rs1451375 | 1 | rs10250513 | chr7:50621488 | FIGNL1 | chr7:50511834-50518088:- | -0.12 | -4.28 | 2.04E-5 | Malaria |